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Title: Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[]anthracene-induced hamster buccal pouch carcinogenesis
Authors: Balakrishnan, Subramanian
Manoharan, Shanmugam
Alias, Linsa Mary
Nirmal, Madavan R
Keywords: bcl-2
Curcumin
DMBA
Ferulic acid
Oral cancer
p53
SCC
Tumor
Issue Date: Feb-2010
Publisher: CSIR
Abstract: The modulating effect of curcumin and ferulic acid was investigated on expression pattern of apoptosis regulatory p53 and bcl-2 proteins in oral squamous cell carcinoma (OSCC). The OSCC was induced in the buccal pouch of golden Syrian hamster by painting with 0.5% 7,12-dimethylbenz[]anthracene (DMBA) three-times a week for 14 weeks. The expression pattern of p53 and bcl-2 proteins was analyzed by immunohistochemical staining. We noticed 100% tumor formation in hamsters painted with DMBA alone for 14 weeks. Overexpression of p53 and bcl-2 proteins was observed in the buccal mucosa of tumor-bearing hamsters. Oral administration of curcumin (80 mg/kg body wt) and ferulic acid (40 mg/kg body wt) to DMBA painted hamsters on days alternate to DMBA painting for 14 weeks completely inhibited tumor formation and down-regulated the expression pattern of p53 and bcl-2 proteins. Our results thus demonstrated the protective role of curcumin and ferulic acid on DMBA-induced abnormal expression of p53 and bcl-2 proteins in the buccal mucosa of golden Syrian hamsters.
Page(s): 7-12
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.47(1) [February 2010]

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