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IJEB Vol.48(03) [March 2010] >


Title: Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd.
Authors: Kaur, Amandeep
Singh, Ranvir
Dey, Chinmoy Sankar
Sharma, Shyam Sundar
Bhutani, Kamlesh K
Singh, Inder Pal
Keywords: Alpinia galanga
Leishmania donovani
Leishmaniasis
Phenylpropanoids
Promastigotes
Issue Date: Mar-2010
Publisher: CSIR
Abstract: Hexane, chloroform and ethyl acetate extracts (100 µg/ml) of Alpinia galanga rhizomes exhibited significant activity in vitro against promastigotes of L. donovani. Twelve compounds namely, methyleugenol (1), p-coumaryl diacetate (2), 1'-acetoxychavicol acetate (3), 1'-acetoxyeugenol acetate (4), trans-p-acetoxycinnamyl alcohol (5), trans-3,4-dimethoxycinnamyl alcohol (6), p-hydroxybenzaldehyde (7), p-hydroxycinnamaldehyde (8), trans-p-coumaryl alcohol (9), galangin (10), trans-p-coumaric acid (11) and galanganol B (12) were isolated from these extracts. Of these, compounds 2, 3, 4 and 5 were found most active in vitro against promastigotes of L. donovani with IC50 values of 39.3, 32.9, 18.9 and 79.9 µM respectively. This is the first report of antileishmanial activity of the extracts and isolated constituents of A. galanga.
Page(s): 314-317
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(03) [March 2010]

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