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Title: Anti-ulcer and antioxidant activity of GutGard<sup>TM</sup>
Authors: Mukherjee, Moumita
Bhaskaran, Natarajan
Srinath, R
Shivaprasad, H N
Allan, J Joshua
Shekhar, D
Agarwal, Amit
Keywords: Anti-ulcer
<i style="">Glycyrrhiza glabra</i>
ORAC assay
Pylorus ligation
Issue Date: Mar-2010
Publisher: CSIR
Abstract: The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard<sup>TM</sup>, a standardized extract of <i style="">Glycyrrhiza glabra </i>commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard<sup>TM</sup> was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and <i style="">p</i>H of gastric fluid. GutGard<sup>TM</sup> dose dependently decreased gastric content, total acidity, ulcer index and increased <i style="">p</i>H of gastric fluid in pylorus ligation ulcer model. In cold-restraint stress- and indomethacin induced ulcer models all the doses of GutGard<sup>TM</sup> decreased the ulcer index and increased the <i style="">p</i>H of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard<sup>TM</sup> exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value. GutGard<sup>TM</sup> possessed anti-ulcerogenic properties that might be afforded via cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.
Description: 269-274
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(03) [March 2010]

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