NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(03) [March 2010] >


Title: Anti-ulcer and antioxidant activity of GutGardTM
Authors: Mukherjee, Moumita
Bhaskaran, Natarajan
Srinath, R
Shivaprasad, H N
Allan, J Joshua
Shekhar, D
Agarwal, Amit
Keywords: Anti-ulcer
Cold-restraint
Glycyrrhiza glabra
GutGardTM
Indomethacin
ORAC assay
Pylorus ligation
Issue Date: Mar-2010
Publisher: CSIR
Abstract: The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGardTM, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGardTM was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. GutGardTM dose dependently decreased gastric content, total acidity, ulcer index and increased pH of gastric fluid in pylorus ligation ulcer model. In cold-restraint stress- and indomethacin induced ulcer models all the doses of GutGardTM decreased the ulcer index and increased the pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGardTM exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value. GutGardTM possessed anti-ulcerogenic properties that might be afforded via cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.
Page(s): 269-274
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(03) [March 2010]

Files in This Item:

File Description SizeFormat
IJEB 48(3) 269-274.pdf93.09 kBAdobe PDFView/Open
 Current Page Visits: 1839 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 624452 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in