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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(03) [March 2010] >
| Title: | Anti-ulcer and antioxidant activity of GutGardTM |
| Authors: | Mukherjee, Moumita
Bhaskaran, Natarajan
Srinath, R
Shivaprasad, H N
Allan, J Joshua
Shekhar, D
Agarwal, Amit |
| Keywords: | Anti-ulcer
Cold-restraint
Glycyrrhiza glabra
GutGardTM
Indomethacin
ORAC assay
Pylorus ligation |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | The present study was undertaken to determine the anti-ulcer and
antioxidant potential of GutGardTM, a standardized extract of Glycyrrhiza glabra commonly known as licorice.
Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGardTM
was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and
indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was
evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. GutGardTM
dose dependently decreased
gastric content, total acidity, ulcer index and increased pH of gastric fluid in pylorus ligation ulcer model. In cold-restraint stress-
and indomethacin induced ulcer
models all the doses of GutGardTM decreased the ulcer index and increased the pH of gastric fluid. The antioxidant
activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGardTM exhibited potent antioxidant
activity with high hydrophilic and lipophilic ORAC value. GutGardTM
possessed anti-ulcerogenic properties that might be afforded via cytoprotective
mechanism by virtue of its antioxidant properties. These results supported the
ethnomedical uses of licorice in the treatment of gastric ulcer. |
| Page(s): | 269-274 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(03) [March 2010]
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