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Title: Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity
Authors: Gohil, Vikrantsinh M
Agrawal, Satyam K
Saxena, Ajit K
Garg, Divita
Gopimohan, C
Bhutani, Kamlesh K
Keywords: Anticancer activity
Aryl hydrazides
Aryl hydrazines
Molecular docking
Issue Date: Mar-2010
Publisher: CSIR
Abstract: Aryl hydrazine and hydrazide analogues were synthesized based on <i style="">p</i>-tolyl hydrazine, isolated as a breakdown product of a secondary metabolite from the mushroom, <i style="">Agaricus bisporus,</i> and tested to be highly active molecule than 5-fluorouracil in <i style="">in vitro</i> anticancer studies. The synthesized analogues were tested for anticancer activity using NCI protocol. Anolgues <b style="">12</b> and <b style="">15</b> emerged as molecules with significant <i style="">in vitro</i> anticancer activity. Molecular docking study revealed the binding orientations of aryl hydrazines and hydrazides analogues in the active sites of thymidylate synthase.
Description: 265-268
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(03) [March 2010]

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