|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(03) [March 2010] >
| Title: | Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity |
| Authors: | Gohil, Vikrantsinh M
Agrawal, Satyam K
Saxena, Ajit K
Garg, Divita
Gopimohan, C
Bhutani, Kamlesh K |
| Keywords: | Anticancer activity
Aryl hydrazides
Aryl hydrazines
Molecular docking |
| Issue Date: | Mar-2010 |
| Publisher: | CSIR |
| Abstract: | Aryl hydrazine and hydrazide analogues were
synthesized based on p-tolyl
hydrazine, isolated as a breakdown product of a secondary metabolite from the
mushroom, Agaricus bisporus, and
tested to be highly active molecule than 5-fluorouracil in in vitro anticancer studies. The synthesized analogues were tested
for anticancer activity using NCI protocol. Anolgues
12 and 15 emerged as molecules with significant in vitro anticancer activity. Molecular docking study revealed the
binding orientations of aryl hydrazines and hydrazides analogues in the active
sites of thymidylate synthase. |
| Page(s): | 265-268 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(03) [March 2010]
|
|
