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Title: Antiproliferative cardenolides from <i style="">Pentopetia androsaemifolia </i>Decne.<i style=""> </i>from the Madagascar rain forest
Authors: Adou, Eba
Miller, James S
Ratovoson, Fidisoa
Birkinshaw, Chris
Andriantsiferana, Rabodo
Rasamison, Vincent E
Kingston, David G I
Keywords: Biodiversity
Drug discovery
<i style="">Pentopetia androsaemifolia</i>
Issue Date: Mar-2010
Publisher: CSIR
Abstract: Plant natural products have historically been very important to drug discovery and development, particularly in the anticancer field. This is illustrated by a discussion of the structures and activities of camptothecin and its analogues, paclitaxel (Taxol<sup>®</sup>), the vinca alkaloids vinblastine and vincristine, and podophyllotoxin and its analogues. A description of the isolation of one new and three known cardenolides from the Madagascar plant <i style="">Pentopetia</i><b style=""> </b><i style="">androsaemifolia </i>is then provided as an example of this approach to drug discovery. The paper concludes with a brief discussion of betulinic acid, an old compound which is being developed into an anticancer and anti-HIV agent, and ipomoeassin F, an interesting antiproliferative compound isolated from a plant collected in Suriname.
Description: 248-257
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(03) [March 2010]

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