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IJEB Vol.48(03) [March 2010] >


Title: Antihyperglycemic activity of compounds isolated from Indian medicinal plants
Authors: Akanksha
Srivastava, Arvind K
Maurya, Rakesh
Keywords: Antihyperglycemic activity
Normoglycemic rat model
PTPase-1B
STZ
Issue Date: Mar-2010
Publisher: CSIR
Abstract: Eleven antidiabetic Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. Antidiabetic principles from five plants were isolated. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with standard drug metformin. Some compounds were also screened in db/db mice. Two compounds (PP-1 and PP-2) inhibited significantly the activity of PTPase-1B in an in vitro system. This might be the underlying mechanism of antihyperglycemic activity of these compounds
Page(s): 294-298
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(03) [March 2010]

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