Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/7398
Title: Elucidation of possible mechanism of analgesic action of <i style="">Valeriana wallichii</i> DC chemotype (patchouli alcohol) in experimental animal models
Authors: Sah, Sangeeta Pilkhwal
Mathela, Chandra S
Chopra, Kanwaljit
Keywords: Analgesic
Essential oil
Iridoids
<i style="">Valeriana wallichii</i>
Issue Date: Mar-2010
Publisher: CSIR
Abstract: <i style="">Valeriana wallichii</i> (Family Valerianaceae), popularly named as Indian valerian, exists as three chemotypes. Aim of the study was to evaluate the effect of <i style="">V. wallichii</i> chemotype (patchouli alcohol) extract (DCME) and essential oil (VPAEO) on experimental models of nociception and to elucidate its possible mechanism of action. Analgesic effect was evaluated using acetic acid induced writhing and tail flick model. DCME and VPAEO (40 and 80 mg/kg, p.o.) significantly inhibited the number of writhings as compared to vehicle treated group. None of the doses of DCME and VPAEO exhibited any effect in tail flick model suggesting only peripheral analgesic activity. When studied for mechanism of action in acetic acid induced writhing, subeffective dose of essential oil significantly potentiated the effect of aspirin while no potentiation was seen in case of extract. These data suggest that essential oil VPAEO exerted peripheral analgesic via inhibition of prostaglandin synthesis.
Description: 289-293
URI: http://hdl.handle.net/123456789/7398
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(03) [March 2010]

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