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Title: Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin
Authors: El-Beshbishy, Hesham A
Mohamadin, Ahmed M
Nagy, Ayman A
Abdel-Naim, Ashraf B
Keywords: Curcumin
Free radical seawemger
Grape seed
Liver enzymes
<i style="">Nigella sativa</i>
Issue Date: Mar-2010
Publisher: CSIR
Abstract: Liver injury was induced in female rats using tamoxifen (TAM). Grape seeds (<i style="">Vitis vinifera</i>) extract (GSE), black seed (<i style="">Nigella sativa</i>) extract (NSE), curcumin (CUR) or silymarin (SYL) were orally administered to TAM-intoxicated rats. Liver histopathology of TAM-intoxicated rats showed pathological changes. TAM-intoxication elicited declines in liver antioxidant enzymes levels (glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase), reduced glutathione (GSH) and GSH/GSSG ratio plus the hepatic elevations in lipid peroxides, oxidized glutathione (GSSG), tumor necrosis factor-alpha (TNF-a) and serum liver enzymes; alanine transaminase, aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase levels. Oral intake of NSE, GSE, CUR or SYL to TAM-intoxicated rats, attenuated histopathological changes and corrected all parameters mentioned above. Improvements were prominent in case of NSE (similarly SYL) > CUR > GSE. Data indicated that NSE, GSE or CUR act as free radicals scavengers and protect TAM-induced liver injury in rats.
Description: 280-288
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(03) [March 2010]

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