Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/7396
Title: Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin
Authors: El-Beshbishy, Hesham A
Mohamadin, Ahmed M
Nagy, Ayman A
Abdel-Naim, Ashraf B
Keywords: Curcumin
Free radical seawemger
Grape seed
Liver enzymes
Nigella sativa
Tamoxifen
Issue Date: Mar-2010
Publisher: CSIR
Abstract: Liver injury was induced in female rats using tamoxifen (TAM). Grape seeds (Vitis vinifera) extract (GSE), black seed (Nigella sativa) extract (NSE), curcumin (CUR) or silymarin (SYL) were orally administered to TAM-intoxicated rats. Liver histopathology of TAM-intoxicated rats showed pathological changes. TAM-intoxication elicited declines in liver antioxidant enzymes levels (glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase), reduced glutathione (GSH) and GSH/GSSG ratio plus the hepatic elevations in lipid peroxides, oxidized glutathione (GSSG), tumor necrosis factor-alpha (TNF-a) and serum liver enzymes; alanine transaminase, aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase levels. Oral intake of NSE, GSE, CUR or SYL to TAM-intoxicated rats, attenuated histopathological changes and corrected all parameters mentioned above. Improvements were prominent in case of NSE (similarly SYL) > CUR > GSE. Data indicated that NSE, GSE or CUR act as free radicals scavengers and protect TAM-induced liver injury in rats.
Description: 280-288
URI: http://hdl.handle.net/123456789/7396
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(03) [March 2010]

Files in This Item:
File Description SizeFormat 
IJEB 48(3) 280-288.pdf1.84 MBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.