|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(10) [October 2007] >
| Title: | Synthesis and evaluation of phenyl substituted sydnones as potential DPPH-radical scavengers |
| Authors: | Mallur, Shanta G
Tiwari, A K
Raju, B China
Babu, K Suresh
Ali, A Zehra
Sastry, B S
Rao, J Madhusudana |
| Keywords: | Sydnones
DPPH radical
Oxidative stress |
| Issue Date: | Oct-2007 |
| Publisher: | CSIR |
| Abstract: | A series of phenyl substituted sydnones has been synthesized and their radical-scavenging activity has been studied on DPPH free radical. Out of eighteen compounds screened, nine compounds show interesting activity. A mechanism is presented whereby sydnones scavenge DPPH radical through donating H-atom at 4th-position. Its strong radical-scavenging activity mainly arises from 1, 2, 3-oxadiazolium-5-olate ring. Different substituents and their positions on the phenyl ring differently influence DPPH scavenging activity and therefore, may provide clues to design and develop better free-radical scavenging sydnones with multiple activities. |
| Page(s): | 1686-1689 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(10) [October 2007]
|
|
