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Title: Synthesis and evaluation of phenyl substituted sydnones as potential DPPH-radical scavengers
Authors: Mallur, Shanta G
Tiwari, A K
Raju, B China
Babu, K Suresh
Ali, A Zehra
Sastry, B S
Rao, J Madhusudana
Keywords: Sydnones;DPPH radical;Oxidative stress
Issue Date: Oct-2007
Publisher: CSIR
Abstract: A series of phenyl substituted sydnones has been synthesized and their radical-scavenging activity has been studied on DPPH free radical. Out of eighteen compounds screened, nine compounds show interesting activity. A mechanism is presented whereby sydnones scavenge DPPH radical through donating H-atom at 4th-position. Its strong radical-scavenging activity mainly arises from 1, 2, 3-oxadiazolium-5-olate ring. Different substituents and their positions on the phenyl ring differently influence DPPH scavenging activity and therefore, may provide clues to design and develop better free-radical scavenging sydnones with multiple activities.
Page(s): 1686-1689
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(10) [October 2007]

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