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|Title:||A new route for the synthesis of (R)-glyceraldehyde acetonide: A key chiral building block|
|Authors:||Babu, K Chandra|
|Keywords:||(R)-Glyceraldehyde acetonide;asymmetric dihydroxylation;allyl 4-methoxybenzoate;chiral building block;Swern oxidation|
|Abstract:||A new route for the synthesis of (R)-glyceraldehyde acetonide via asymmetric dihydroxylation of allyl 4-methoxybenzoate using the (DHQ)2PHAL, K2OsO4·2H2O catalyst system is described. This route involves the asymmetric dihydroxylation of allyl 4-methoxybenzoate, acetonide protection of vicinyl dihydroxyl groups followed by cleavage of p-methoxybenzoate ester and subsequent oxidation to give the (R)-glyceraldehyde acetonide.|
|Appears in Collections:||IJC-B Vol.49B(02) [February 2010]|
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