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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(02) [February 2010] >
| Title: | Chemoselective reaction of malononitrile with imine-ones and antifungal potential of products |
| Authors: | Sidhu, Anjali
Sharma, J R
Rai, Mangat |
| Keywords: | 1-[4-(Benzylideneamino)phenyl]ethanones
malononitrile
imine-ones
2-benzylidenemalononitriles
antifungal potential |
| Issue Date: | Feb-2010 |
| Publisher: | CSIR |
| Abstract: | Condensation of malononitrile with 1-[4-(benzylideneamino)phenyl]ethanones 1-10, the compounds containing both carbon-nitrogen and carbon-oxygen double bonds, in equimolar ratio results in the formation of solid products, identified as 2-benzylidenemalononitrile and its derivatives 1a-10a on the basis of elemental analysis and spectral studies. The reaction of 1-10 with two moles of malononitrile also yields the same products 1a-10a by a chemoselective attack of malononitrile on carbon-nitrogen double bond only rather than on both the reactive centres. The synthesized compounds 1a-10a have been evaluated for antifungal potential against Alternaria alternata, Colletotrichum capsici, Fusarium oxysporum, Myrothecium roridum and Ustilago tritici. Some of the compounds have been found to possess promising antifungal potential against the test fungi. |
| Page(s): | 247-250 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(02) [February 2010]
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