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Title: Chemoselective reaction of malononitrile with imine-ones and antifungal potential of products
Authors: Sidhu, Anjali
Sharma, J R
Rai, Mangat
Keywords: 1-[4-(Benzylideneamino)phenyl]ethanones
antifungal potential
Issue Date: Feb-2010
Publisher: CSIR
Abstract: Condensation of malononitrile with 1-[4-(benzyl­idene­amino)­phenyl]ethanones <b>1-10</b>, the compounds containing both carbon-nitrogen and carbon-oxygen double bonds, in equimolar ratio results in the formation of solid products, identified as 2-benzylidenemalononitrile and its derivatives <b>1a-10a</b> on the basis of elemental analysis and spectral studies. The reaction of <b>1-10</b> with two moles of malononitrile also yields the same products <b>1a-10a</b> by a chemoselective attack of malononitrile on carbon-nitrogen double bond only rather than on both the reactive centres. The synthesized compounds <b>1a-10a</b> have been evaluated for antifungal potential against <i>Alternaria alternata, Colletotrichum capsici, Fusarium oxysporum, Myrothecium roridum </i>and <i>Ustilago tritici</i>. Some of the compounds have been found to possess promising antifungal potential against the test fungi.
Description: 247-250
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(02) [February 2010]

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