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IJC-B Vol.49B(02) [February 2010] >

Title: Syntheses of aromatic aldehyde imine derivatives of 2-thiobenzyl-1,3,4-thiadiazole and evaluation of their anticonvulsant activity
Authors: Ahmed, Bahar
Yusuf, Md.
Keywords: 1,3,4-Thiadioazole
maximum electroshock seizure method
rotarod method
ethanol potentiation test
Issue Date: Feb-2010
Publisher: CSIR
Abstract:  Benzyl and chlorobenzyl substituted 1, 3, 4-thiadiazole imine derivatives have been prepared by refluxing aromatic aldehyde imine derivatives and benzyl chloride/ 4-chloro benzyl chloride in ethanolic potassium hydroxide. The structures of the compounds have been determined by spectral and chemical methods. The anticonvulsant activity has been carried out using Karl et al. method. All the reported compounds show good anticonvulsant activity wherein chlorobenzyl substituted compounds show potent anticonvulsant activity against phenytoin used as the standard reference drug. Neurotoxicity has been screened through the Rota rod and ethanol potentiation test. The compounds did not show any neurotoxicity.
Page(s): 241-246
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(02) [February 2010]

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