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IJEB Vol.48(02) [February 2010] >


Title: Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats
Authors: Shanmugam, K R
Ramakrishna, CH
Mallikarjuna, K
Reddy, K Sathyavelu
Keywords: Alcohol
Antioxidants
Oxidative stress
Histopathology
Kidney
Rats
Issue Date: Feb-2010
Publisher: CSIR
Abstract: Superoxide dismutase, ascorbic acid, glutathione and uric acid levels were decreased and xanthine oxidase, glutathione-s-transferase activities were increased in alcohol treated (2 g/kg body weight, once daily for 30 days) group. However, treatment with ethanolic extract of ginger (100 mg/kg, 200 mg/kg body weight, po, once daily for 30 days) these parameters came to normalcy showing the antioxidant effect of ginger. The antioxidant compounds of ginger may modulate the oxidative stress parameters. The biochemical findings were supplemented by histopathological examination of the kidney. Severe congestion and degenerative changes in tubules in alcohol treated rats were restored by ginger extract treatment. The results confirm the renal protective effect of ginger in alcohol treated rats.
Page(s): 143-149
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(02) [February 2010]

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