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Title: Anticancer potential of animal venoms and toxins
Authors: Gomes, Antony
Bhattacharjee, Pushpak
Mishra, Roshnara
Biswas, Ajoy K.
Dasgupta, Subir Chandra
Giri, Biplab
Debnath, Anindita
Gupta, Shubho Das
Das, Tanaya
Gomes, Aparna
Keywords: Anticancer activity;Combination therapy;Toxins;Venoms
Issue Date: Feb-2010
Publisher: CSIR
Abstract: Anticancer drug development from natural resources are ventured throughout the world. Animal venoms and toxins a potential bio resource and a therapeutic tool were known to man for centuries through folk and traditional knowledge. The biodiversity of venoms and toxins made it a unique source of leads and structural templates from which new therapeutic agents may be developed. Venoms of several animal species (snake, scorpion, toad, frog etc) and their active components (protein and non protein toxins, peptides, enzymes, etc) have shown therapeutic potential against cancer. In the present review, the anticancer potential of venoms and toxins from snakes, scorpions, toads and frogs has been discussed. Some of these molecules are in the clinical trials and may find their way towards anticancer drug development in the near future. The implications of combination therapy of natural products in cancer have been discussed.
Page(s): 93-103
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(02) [February 2010]

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