NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(10) [October 2007] >


Title: N and N+1 cap positional effects of (D) alanine in the 310 type helical model peptide Boc-(D)Glu-Ala-Ala-Lys-NHMe
Authors: Bobade, V D
Mhaske, P C
Keywords: 3₁₀ Helix
II’ turn
Reverse turn
D amino acids
NMR studies
Issue Date: Oct-2007
Publisher: CSIR
Abstract: The N (Ala₂) and N+1(Ala₃) cap positional alanine in the 3₁₀ helical model peptide Boc-(D)Glu₁-Ala₂-Ala₃-Lys₄-NHMe, 2 is substituted with a (D)alanine. An NMR enquiry using solvents that promote appreciable ordering of peptide 2, against random conformation of the parent (L)Glu₁ peptide 1, establishes that D alanine partially disorders the type II’ turn templated 3₁₀ type helical fold and distorts it in a position dependent manner, more strongly from N cap position than from N+1 cap position.
Page(s): 1679-1685
ISSN: 0376-4699
Source:IJC-B Vol.46B(10) [October 2007]

Files in This Item:

File Description SizeFormat
IJCB 46B(10) (2007) 1679-1685.pdf210.77 kBAdobe PDFView/Open
 Current Page Visits: 788 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 638796 since 06-Feb-2009  Last updated on 15-Dec-2014Webmaster: nopr@niscair.res.in