|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(10) [October 2007] >
| Title: | N and N+1 cap positional effects of (D) alanine in the 310 type helical model peptide Boc-(D)Glu-Ala-Ala-Lys-NHMe |
| Authors: | Bobade, V D
Mhaske, P C |
| Keywords: | 3₁₀ Helix
II’ turn
Reverse turn
D amino acids
NMR studies |
| Issue Date: | Oct-2007 |
| Publisher: | CSIR |
| Abstract: | The N (Ala₂) and N+1(Ala₃) cap positional alanine in the 3₁₀ helical model peptide Boc-(D)Glu₁-Ala₂-Ala₃-Lys₄-NHMe, 2 is substituted with a (D)alanine. An NMR enquiry using solvents that promote appreciable ordering of peptide 2, against random conformation of the parent (L)Glu₁ peptide 1, establishes that D alanine partially disorders the type II’ turn templated 3₁₀ type helical fold and distorts it in a position dependent manner, more strongly from N cap position than from N+1 cap position. |
| Page(s): | 1679-1685 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(10) [October 2007]
|
|
