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Title: | N and N+1 cap positional effects of (D) alanine in the 310 type helical model peptide Boc-(D)Glu-Ala-Ala-Lys-NHMe |
Authors: | Bobade, V D Mhaske, P C |
Keywords: | 3₁₀ Helix;II’ turn;Reverse turn;D amino acids;NMR studies |
Issue Date: | Oct-2007 |
Publisher: | CSIR |
Abstract: | The N (Ala₂) and N+1(Ala₃) cap positional alanine in the 3₁₀ helical model peptide Boc-(D)Glu₁-Ala₂-Ala₃-Lys₄-NHMe, 2 is substituted with a (D)alanine. An NMR enquiry using solvents that promote appreciable ordering of peptide 2, against random conformation of the parent (L)Glu₁ peptide 1, establishes that D alanine partially disorders the type II’ turn templated 3₁₀ type helical fold and distorts it in a position dependent manner, more strongly from N cap position than from N+1 cap position. |
Page(s): | 1679-1685 |
URI: | http://hdl.handle.net/123456789/730 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.46B(10) [October 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 46B(10) (2007) 1679-1685.pdf | 210.77 kB | Adobe PDF | View/Open |
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