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Title: Hypolipidemic activity of Hibiscus rosa sinensis root in rats
Authors: Kumar, Vishnu
Singh, Pradyumn
Chander, Ramesh
Mahdi, Farzana
Singh, Sushma
Singh, Ranjana
Keywords: Hibiscus rosa sinensis
Triton
Cholesterol hyperlipidemia
Hypolipidemic agent
Post-heparin lipolytic activity
Hepatic lipoprotein lipase activity
Hepatic steatosis
Issue Date: Dec-2009
Publisher: CSIR
Abstract:  The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis.
Page(s): 507-510
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.46(6) [December 2009]

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