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IJBB Vol.46(6) [December 2009] >


Title: Emerging Molecular Targets for the Treatment of Asthma
Authors: Sharma, Pawan
Halayko, Andrew J
Keywords: Asthma
Airway hyperresponsiveness
Inflammation
Airway remodeling
PDE4 inhibitors
Statins
Rho kinase
Cytokines
Bronchodilators
PI-3 kinase inhibitors
Antisense oligonucleotides
Transcription factors
Kinase inhibitors
CpG oligonucleotides
H4 receptors
Issue Date: Dec-2009
Publisher: CSIR
Abstract: Current therapeutic approaches for the treatment of asthma have limitations in their ability to target all the features of the disease. Indeed, existing pharmacological asthma therapies are based on decades old strategies that were developed prior to the rapid growth in knowledge stemming from cell and molecular biology in the past decade. Thus, there is an unmet need for developing new drugs to target these features along with improved efficacy and safety. In the present review, the limitations of prevalent pharmacological asthma therapy are discussed briefly, and some explanations are suggested as to why new therapeutic targets are required to treat asthma, and finally directions for novel asthma therapies are proposed.
Page(s): 447-460
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.46(6) [December 2009]

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