Please use this identifier to cite or link to this item:
Title: Emerging Molecular Targets for the Treatment of Asthma
Authors: Sharma, Pawan
Halayko, Andrew J
Keywords: Asthma;Airway hyperresponsiveness;Inflammation;Airway remodeling;PDE4 inhibitors;Statins;Rho kinase;Cytokines;Bronchodilators;PI-3 kinase inhibitors;Antisense oligonucleotides;Transcription factors;Kinase inhibitors;CpG oligonucleotides;H4 receptors
Issue Date: Dec-2009
Publisher: CSIR
Abstract: Current therapeutic approaches for the treatment of asthma have limitations in their ability to target all the features of the disease. Indeed, existing pharmacological asthma therapies are based on decades old strategies that were developed prior to the rapid growth in knowledge stemming from cell and molecular biology in the past decade. Thus, there is an unmet need for developing new drugs to target these features along with improved efficacy and safety. In the present review, the limitations of prevalent pharmacological asthma therapy are discussed briefly, and some explanations are suggested as to why new therapeutic targets are required to treat asthma, and finally directions for novel asthma therapies are proposed.
Page(s): 447-460
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.46(6) [December 2009]

Files in This Item:
File Description SizeFormat 
IJBB 46(6) 447-460.pdf175.17 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.