Please use this identifier to cite or link to this item:
http://nopr.niscair.res.in/handle/123456789/7247
Title: | Homocysteine, Hydrogen sulfide (H2S) and NMDA-Receptor in Heart Failure |
Authors: | Tyagi, Neetu Mishra, Paras K Tyagi, Suresh C |
Keywords: | Mitochondrial matrix metalloproteinase;Myocyte mechanics;Calcium transient;Mitochondrial permeability;NMDA-R1;Hydrogen sulfide;Cystathionine β-synthase Cystathionine ![]() |
Issue Date: | Dec-2009 |
Publisher: | CSIR |
Abstract: | Mitochondrial mechanism of oxidative stress and matrix metalloproteinase (MMP) activation was unclear. Our recent data suggested that MMPs are localized to mitochondria and activated by peroxynitrite, which causes cardiovascular remodeling and failure. Recently, we have demonstrated that elevated levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy) increase oxidative stress in the mitochondria. Although HHcy causes heart failure, interestingly, it is becoming very clear that Hcy can generate hydrogen sulfide (H2S), if the enzymes cystathionine β-synthase (CBS) and cystathionine ![]() |
Page(s): | 441-446 |
URI: | http://hdl.handle.net/123456789/7247 |
ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
Appears in Collections: | IJBB Vol.46(6) [December 2009] |
Files in This Item:
File | Description | Size | Format | |
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IJBB 46(6) 441-446.pdf | 92.39 kB | Adobe PDF | View/Open |
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