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IJC-A Vol.49A(01) [January 2010] >

Title: Electrochemical investigations of prednisone using fullerene-C60-modified edge plane pyrolytic graphite electrode
Authors: Goyal, Rajendra N
Singh, Sudhanshu P
Chatterjee, Sanghamitra
Bishnoi, Sunita
Keywords: Electrochemistry
Edge plane pyrolytic graphite electrode
Embedded metallic impurities
Issue Date: Jan-2010
Publisher: CSIR
IPC CodeInt. Cl.9 G01N27/00
Abstract:  Electrochemical investigation of prednisone has been carried out in phosphate buffer media using fullerene-C60-modified edge plane pyrolytic graphite electrode. The reduction occurs as a single well-defined pH dependent peak. The fullerene modified electrode shows excellent improvement in peak current and marked lowering in peak potential as compared to the various substrates such as fullerene modified glassy carbon electrode and indium tin oxide, gold and basal plane pyrolytic graphite electrodes. A comparative study of the voltammetric response of prednisone at acid treated (purified and super-purified) and untreated fullerene modified electrode shows that the enhanced reduction peak current is more prominent at the untreated fullerene modified electrode. The product corresponding to 2e, 2H+ reduction has been isolated and characterized. The detection limit and sensitivity of prednisone have been found to be 4.8 × 10-8 M and 0.2766 µA µM-1 respectively. The practical application of the studies is demonstrated by the determination of prednisone in real samples and good agreement with results obtained by HPLC is observed.
Page(s): 26-33
ISSN: 0975-0975(Online); 0376-4710(Print)
Source:IJC-A Vol.49A(01) [January 2010]

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