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IJC-B Vol.46B(11) [November 2007] >


Title: Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and evaluation of bio-activity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles
Authors: Kumar, Parvin
Jag Mohan
Makrandi, J K
Keywords: ⍺-Haloketones
PPA
POCl₃
Diuretic
Antibacterial
Antifungal
Issue Date: Nov-2007
Publisher: CSIR
Abstract: Synthesis of 2-(3'-bromophenyl)-5-(p-bromophenyl) thiazolo[3,2-b]-s-triazoles 4 has been achieved starting from the appropriate 5-mercapto-3-(3'-bromo phenyl)-s-triazole 2. Compound 2 on condensation with α-haloketones gives the ketones 3 which on cyclization with PPA afford 5-(p-bromophenyl)-2-(3'-bromophenyl)thiazolo[3,2-b]-s-triazoles 4 and not the isomeric thiazolo[2,3-c]-s-triazoles 6. This has been established by an unequivocal synthesis of 6 through POCl3 cyclization of 3'-bromobenzoylhydrazino-4-p-bromophenyl-thiazole hydrobromide 5. The diuretic, antibacterial and antifungal activities of some of the compounds have also been evaluated.
Page(s): 1883-1885
ISSN: 0376-4699
Source:IJC-B Vol.46B(11) [November 2007]

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