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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(11) [November 2007] >
| Title: | Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and evaluation of bio-activity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles |
| Authors: | Kumar, Parvin
Jag Mohan
Makrandi, J K |
| Keywords: | ⍺-Haloketones
PPA
POCl₃
Diuretic
Antibacterial
Antifungal |
| Issue Date: | Nov-2007 |
| Publisher: | CSIR |
| Abstract: | Synthesis of 2-(3'-bromophenyl)-5-(p-bromophenyl) thiazolo[3,2-b]-s-triazoles 4 has been achieved starting from the appropriate 5-mercapto-3-(3'-bromo phenyl)-s-triazole 2. Compound 2 on condensation with α-haloketones gives the ketones 3 which on cyclization with PPA afford
5-(p-bromophenyl)-2-(3'-bromophenyl)thiazolo[3,2-b]-s-triazoles 4 and not the isomeric thiazolo[2,3-c]-s-triazoles 6. This has been established by an unequivocal synthesis of 6 through POCl3 cyclization of 3'-bromobenzoylhydrazino-4-p-bromophenyl-thiazole hydrobromide 5. The diuretic, antibacterial and antifungal activities of some of the compounds have also been evaluated. |
| Page(s): | 1883-1885 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(11) [November 2007]
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