Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/717
Title: Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and evaluation of bio-activity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles
Authors: Kumar, Parvin
Jag Mohan
Makrandi, J K
Keywords: ⍺-Haloketones;PPA;POCl₃;Diuretic;Antibacterial;Antifungal
Issue Date: Nov-2007
Publisher: CSIR
Abstract: Synthesis of 2-(3'-bromophenyl)-5-(p-bromophenyl) thiazolo[3,2-b]-s-triazoles 4 has been achieved starting from the appropriate 5-mercapto-3-(3'-bromo phenyl)-s-triazole 2. Compound 2 on condensation with α-haloketones gives the ketones 3 which on cyclization with PPA afford 5-(p-bromophenyl)-2-(3'-bromophenyl)thiazolo[3,2-b]-s-triazoles 4 and not the isomeric thiazolo[2,3-c]-s-triazoles 6. This has been established by an unequivocal synthesis of 6 through POCl3 cyclization of 3'-bromobenzoylhydrazino-4-p-bromophenyl-thiazole hydrobromide 5. The diuretic, antibacterial and antifungal activities of some of the compounds have also been evaluated.
Page(s): 1883-1885
URI: http://hdl.handle.net/123456789/717
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(11) [November 2007]

Files in This Item:
File Description SizeFormat 
IJCB 46B(11) (2007) 1883-1885.pdf121.76 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.