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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(11) [November 2007] >
| Title: | Synthesis and antimicrobial screening of 5-(4,7-dimethyl-2-oxo-2H- benzopyran- 6-ylazo)-2-methyl-6- morpholin-4-yl-2, 3-dihydro-3H-pyrimidin-4-one and 5-(4,7-dimethyl-2-oxo-2H- benzopyran-6-ylazo)- 2-methyl-6-piperidin-1-yl-2,3- dihydro-3H-pyrimidin-4-one |
| Authors: | Mulwad, Vinata V
Mayekar, Sagar A |
| Keywords: | 6-Aminocoumarin
Enaminonitrile
Pyrimidine
Antimicrobial activity
Diazotized. |
| Issue Date: | Nov-2007 |
| Publisher: | CSIR |
| Abstract: | The coupling reaction of the diazonium solution of the
6-aminocoumarins (1a-c) with malononitrile affords the corre-sponding 2-[(4,7-dimethyl-2-oxo-2H-benzopyran-6-yl)- hydra-zono]-malononitrile (2a-c) which on refluxing with morpholine and piperidine separately yields the corresponding 3-amino-2-(4,7-dimethyl-2-oxo-2H-benzopyran- 6-ylazo)-3-morpholin-4-yl-acrylonitrile (3a-c) and 3-amino-2-(4,7-dimethyl-2-oxo-2H-benzopyran-6- ylazo)-3-piperidin-1-yl-acrylonitrile (3d-f) respec-tively. The enaminonitrile derivatives (3a-f) on heating with ace-tic anhydride give the corresponding 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)- 2-methyl-6-morpholin-4-yl-2,3-dihydro-3H- pyrimidin-4-one and 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)- 2-methyl-6-piperidin-1-yl-2,3-dihydro-3H- pyrimidin-4-one (4a-f). The structures of the compounds (2a-c), (3a-f) and (4a-f) have been established on the basis of spectral and analytical data. All the above compounds have been screened for their antimicro-bial activities and are found to possess significant antibacterial activities. |
| Page(s): | 1873-1878 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(11) [November 2007]
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