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IJC-B Vol.49B(01) [January 2010] >


Title: Synthesis of some novel chalcones of phthalimidoester possessing good anti-inflammatory and antimicrobial activity
Authors: Gaikwad, Kishor V
Gaikwad, Sandip V
Jadhav, Satish B
Rathod, Shantilal D
Keywords: Ester of phthalimides
chalcones
anti-inflammatory and antimicrobial activity
Issue Date: Jan-2010
Publisher: CSIR
Abstract: A new series of methyl-2-[substituted benzylidine]-4-[2-(ph¬≠thalimide) ethoxy] acetoacetate, 5a-h have been synthesized from the combination of methyl-4-[2-(phthalimido) ethoxy] aceto¬≠acetate, 3 and substituted benzaldehyde 4a-h which results in both anti-inflammatory and antimicrobial active compound. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. These compounds have been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat pow oedema model. Compounds 5a,b,c show marked activity comparable to indomethacin. Compounds 5a,b,c,g show significant antimicrobial activity.
Page(s): 131-136
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(01) [January 2010]

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