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Title: Synthesis of some novel chalcones of phthalimidoester possessing good anti-inflammatory and antimicrobial activity
Authors: Gaikwad, Kishor V
Gaikwad, Sandip V
Jadhav, Satish B
Rathod, Shantilal D
Keywords: Ester of phthalimides
anti-inflammatory and antimicrobial activity
Issue Date: Jan-2010
Publisher: CSIR
Abstract: A new series of methyl-2-[substituted benzylidine]-4-[2-(ph­thalimide) ethoxy] acetoacetate, <b style="">5a-h</b> have been synthesized from the combination of methyl-4-[2-(phthalimido) ethoxy] aceto­acetate, <b style="">3 </b>and substituted benzaldehyde <b style="">4a-h</b> which results in both anti-inflammatory and antimicrobial active compound. These compounds have been characterized by IR, <sup>1</sup>H NMR, mass spectral and elemental analysis. These compounds have been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat pow oedema model. Compounds <b style="">5a,b,c </b>show marked activity comparable to indomethacin. Compounds <b style="">5a,b,c,g</b> show significant antimicrobial activity.
Description: 131-136
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(01) [January 2010]

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