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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(01) [January 2010] >
| Title: | Synthesis of some novel chalcones of phthalimidoester possessing good anti-inflammatory and antimicrobial activity |
| Authors: | Gaikwad, Kishor V
Gaikwad, Sandip V
Jadhav, Satish B
Rathod, Shantilal D |
| Keywords: | Ester of phthalimides
chalcones
anti-inflammatory and antimicrobial activity |
| Issue Date: | Jan-2010 |
| Publisher: | CSIR |
| Abstract: | A new series of methyl-2-[substituted benzylidine]-4-[2-(phthalimide) ethoxy] acetoacetate, 5a-h have been synthesized from the combination of methyl-4-[2-(phthalimido) ethoxy] acetoacetate, 3 and substituted benzaldehyde 4a-h which results in both anti-inflammatory and antimicrobial active compound. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. These compounds have been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat pow oedema model. Compounds 5a,b,c show marked activity comparable to indomethacin. Compounds 5a,b,c,g show significant antimicrobial activity. |
| Page(s): | 131-136 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(01) [January 2010]
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