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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(01) [January 2010] >
| Title: | Synthesis, spectral studies and biological activity of novel 1H-1,4-diazepine derivatives |
| Authors: | Kumar, Rajesh
Joshi, Yogesh C |
| Keywords: | 1,4-Diazepines
 -diketones
-ketoesters
pyrimidin-7-one
lanthanum (III) nitrate hexahydrate
thylenediamine |
| Issue Date: | Jan-2010 |
| Publisher: | CSIR |
| Abstract: | Sulphonation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d) pyrimidin-7-one 1 with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy) phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one 2. Further, compound 2 is condensed with different β-diketones/β-ketoesters 3a-e, to obtain new β-diketones/β-ketoesters 4a-e. The synthesized new β-diketones/β-ketoesters and ethylenediamine (EDA) gives biologically active 1H-1,4-diazepines 5a-e. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds 5a-e have been screened for antimicrobial, antifungal and anthelmintic activity. |
| Page(s): | 84-88 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(01) [January 2010]
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