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IJC-B Vol.49B(01) [January 2010] >


Title: Synthesis, spectral studies and biological activity of novel 1H-1,4-diazepine derivatives
Authors: Kumar, Rajesh
Joshi, Yogesh C
Keywords: 1,4-Diazepines
-diketones
-ketoesters
pyrimidin-7-one
lanthanum (III) nitrate hexahydrate
thylenediamine
Issue Date: Jan-2010
Publisher: CSIR
Abstract: Sulphonation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d) pyrimidin-7-one 1 with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy) phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one 2. Further, compound 2 is condensed with different β-diketones/β-ketoesters 3a-e, to obtain new β-diketones/β-ketoesters 4a-e. The synthesized new β-diketones/β-ketoesters and ethylenediamine (EDA) gives biologically active 1H-1,4-diazepines 5a-e. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds 5a-e have been screened for antimicrobial, antifungal and anthelmintic activity.
Page(s): 84-88
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(01) [January 2010]

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