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Title: Synthesis, spectral studies and biological activity of novel 1<i>H</i>-1,4-diazepine derivatives
Authors: Kumar, Rajesh
Joshi, Yogesh C
Keywords: 1,4-Diazepines
<img src='/image/spc_char/beta.gif' border=0>-diketones
<img src='/image/spc_char/beta.gif' border=0>-ketoesters
lanthanum (III) nitrate hexahydrate
Issue Date: Jan-2010
Publisher: CSIR
Abstract: Sulphonation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7<i>H</i>-pyrazolo[4,3-<i style="">d</i>) pyrimidin-7-one<b> 1 </b>with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy) phenyl]-1-methyl-3-propyl-1,6-dihydro-7<i>H</i>-pyrazolo[4,3-<i style="">d</i>] pyrimidin-7-one <b>2</b>. Further, compound <b>2</b> is condensed with different β-diketones/β-ketoesters <b>3a-e,</b> to obtain new β-diketones/β-ketoesters <b>4a-e</b>.<b> </b>The synthesized new β-diketones/β-ketoesters and ethylenediamine (EDA) gives biologically active 1<i>H</i>-1,4-diazepines <b>5a-e</b>. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds <b>5a-e</b> have been screened for antimicrobial, antifungal and anthelmintic activity.
Description: 84-88
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(01) [January 2010]

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