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|Title:||Synthesis, spectral studies and biological activity of novel 1H-1,4-diazepine derivatives|
Joshi, Yogesh C
|Keywords:||1,4-Diazepines;-diketones;-ketoesters;pyrimidin-7-one;lanthanum (III) nitrate hexahydrate;thylenediamine|
|Abstract:||Sulphonation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d) pyrimidin-7-one 1 with chlorosulphonic acid affords 5-[(5-chlorosulphonyl-2-ethoxy) phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one 2. Further, compound 2 is condensed with different β-diketones/β-ketoesters 3a-e, to obtain new β-diketones/β-ketoesters 4a-e. The synthesized new β-diketones/β-ketoesters and ethylenediamine (EDA) gives biologically active 1H-1,4-diazepines 5a-e. All the newly synthesized compounds are characterized by elemental analysis and spectral studies. The compounds 5a-e have been screened for antimicrobial, antifungal and anthelmintic activity.|
|Appears in Collections:||IJC-B Vol.49B(01) [January 2010]|
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