NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(01) [January 2010] >

Title: An efficient concomitant synthesis of O-succinimidyl-(9H-fluoren-9-yl methoxy carbonylamino)peptidyl carbamates and their application in the synthesis of oligo--peptidyl ureas
Authors: Sureshbabu, Vommina V
Chennakrishnareddy, Gundala
Naik, Shankar A
Keywords: Oligo--ureas
Curtius rearrangement
peptide acid azides
peptidyl carbamates
Issue Date: Jan-2010
Publisher: CSIR
Abstract:  An efficient method for the synthesis of O-succinimidyl (9H-fluorene-9-yl methoxycarbonylamine) peptidyl carbamates from the corresponding N-Fmoc peptidyl isocyanates through the concomitant Curtius rearrangement of N-Fmoc peptidyl acid azide and coupling with N-hydroxysuccinimide is described. The introduction of urea moiety at various positions in peptidyl backbone of VALVAL hexapeptide sequence has been carried out by the fragment coupling using peptidyl carbamates. All the oligo--peptidyl ureas are isolated as crystalline solids in 80-85% yield and have been fully characterized by 1H and 13C NMR and mass spectrometry.
Page(s): 69-76
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(01) [January 2010]

Files in This Item:

File Description SizeFormat
IJCB 49B(1) 69-76.pdf197.39 kBAdobe PDFView/Open
 Current Page Visits: 1188 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 170709 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: