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IJC-B Vol.46B(11) [November 2007] >


Title: Microwave assisted synthesis of indole and furan derivatives possessing good anti-inflammatory and analgesic activity
Authors: Sondhi, Sham M
Jain, Shubhi
Rani, Reshma
Kumar, Ashok
Keywords: Microwave
Indole
Furan
Anti-inflammatory
Analgesic
Issue Date: Nov-2007
Publisher: CSIR
Abstract: Indole-2-carboxylic acid on condensation with benzene sulfonyl hydrazide and p-toluene sulfonyl hydrazide gives condensation products 1a and 1b. 1H-Tetrazole-5-acetic acid, hydantoin-5-acetic acid, orotic acid, 5-bromo nicotinic acid and indole 2-carboxylic acid have been condensed with furfuryl amine to give corresponding condensation products 2a-e whereas condensation of succinic acid and adipic acid with furfuryl amine gives products 3a and 3b respectively. 3,5-Pyrazole dicarboxlic acid, 4,5-imidazole dicarboxylic acid and 3-carboxy-1,4-dimethyl pyrole-2-acetic acid on condensation with furfuryl amine give compounds 4, 5 and 6. All these compounds i.e. 1a,b, 2a-e, 3a,b, 4, 5 and 6 have been characterized by spectroscopic means and have been screened for anti-inflammatory and analgesic activity. Compounds 2a, and 5 exhibit good anti-inflammatory and 2a, 2c and 5 exhibit good analgesic activity.
Page(s): 1848-1854
ISSN: 0376-4699
Source:IJC-B Vol.46B(11) [November 2007]

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