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Title: Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists
Authors: Bansi Lal
Gangopadhyay, Ashok K
Jagtap, P G
Tanpure, Rajendra
Rao, V S V V
Gupte, Ravindra D
Subbarayan, P
Asudani, Gope
Keywords: Glycoprotein GP IIb-IIIa receptor
S-methyl isothiourea
Hydrogen bond donor site
Issue Date: Nov-2007
Publisher: CSIR
Abstract: Design and synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on isoindolone skeleton has been described. This scaffold has been derived from earlier reported pseudopeptides. Synthesis by a novel route has been achieved. Few molecules show very potent in vitro activity. Further identification of probable additional hydrogen bond donor site has been described.
Description: 1815-1832
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(11) [November 2007]

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