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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(11) [November 2007] >
| Title: | Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists |
| Authors: | Bansi Lal
Gangopadhyay, Ashok K
Jagtap, P G
Tanpure, Rajendra
Rao, V S V V
Gupte, Ravindra D
Subbarayan, P
Asudani, Gope |
| Keywords: | Glycoprotein GP IIb-IIIa receptor
Guanidine
Isoindolone
S-methyl isothiourea
Hydrogen bond donor site |
| Issue Date: | Nov-2007 |
| Publisher: | CSIR |
| Abstract: | Design and synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on isoindolone skeleton has been described. This scaffold has been derived from earlier reported pseudopeptides. Synthesis by a novel route has been achieved. Few molecules show very potent in vitro activity. Further identification of probable additional hydrogen bond donor site has been described. |
| Page(s): | 1815-1832 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.46B(11) [November 2007]
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