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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(03) [March 2006] >
| Title: | Cytosolic sulfotransferases |
| Authors: | Nimmagadda, Deepthi
Cherala, Ganesh
Ghatta, Srinivas |
| Keywords: | Breast cancer
Carcinogens Sulfoconjugation
PAPS
Substrate binding region
Sulfotransferases |
| Issue Date: | Mar-2006 |
| Publisher: | CSIR |
| Abstract: | Sulfoconjugation (Sulfation or Sulfonation) is an important
reaction in the phase II biotransformation of a wide number of endogenous and
foreign chemicals, including: drugs, toxic chemicals, hormones, and neurotransmitters.
The reaction is catalyzed by the members of the cytosolic sulfotransferase
(SULT) superfamily, consisting of ten functional genes in humans. Sulfation
reaction in living cells is reversed by sulfatase, which hydrolyses the
sulfonated conjugates. It has a major role in regulating the endocrine status
of an individual by modulating the activity of steroid hormones, their
biosynthesis, and the metabolism of catecholamines. Sulfonation is a key
reaction in the body's ‘chemical’ defense against xenobiotics. Although the
primary function of sulfoconjugation is to permit detoxification of the
compound, it also results in the activation of chemical procarcinogens, such as
certain dietary and environmental agents into carcinogens. In this review, we
summarize our current understanding of the structure of mammalian cytosolic
sulfotransferases and their role in human steroid associated cancers and in the
bioactivation of chemical carcinogens. |
| Page(s): | 171-182 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(03) [March 2006]
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