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Title: Pyrrolidine catalyzed regioselective and diastereoselective direct aldol reaction in water
Authors: Mahajan, Dinesh
Chimni, Swapandeep Singh
Keywords: Direct aldol reaction;Pyrrolidine catalysis;Regioselective synthesis;Diastereoselective synthesis;Aqueous media;Organocatalysis
Issue Date: Aug-2007
Publisher: CSIR
Abstract: Pyrrolidine catalyzed direct aldol reaction of methyl ketones other than acetone with 4-nitrobenzaldehyde in water affords linear aldol addition product arising from the selective attack of the unsubstituted carbon of the unsymmetrical ketone. The present methodology provides an experimentally simple and green process for regioselective synthesis of -hydroxyketones in water.
Page(s): 1355-1358
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(08) [August 2007]

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