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Title: Rotational equilibria in boat conformations of N-acyl-r-2,c-6-di(2-hetero- aryl)piperidin-4-ones using NMR spectra and semiempirical MO calculations
Authors: Thenmozhiyal, J C
Venkatraj, M
Ponnuswamy, S
Jeyaraman, R
Keywords: N-acyl-r-2;c-6-di(2-heteroaryl)piperidin-4-one;NMR spectra;Semiempirical MO calculation;Boat conformation;N-acetyl;N-benzoyl;N-phenylcarbamoyl
Issue Date: Sep-2007
Publisher: CSIR
Abstract: Four N-acyl-r-2,c-6-di(2-heteroaryl)piperidin-4-ones 3-6 have been prepared and their conformational preferences examined using ¹H and ¹³C NMR spectral studies and semiempirical MO calculations. Solution state conformational studies on the compounds 3-6 by ¹H and ¹³C NMR spectral methods indicated the preference for the boat conformation with coplanar orientation of N-acyl groups. The energy barrier for N-C rotation in 3 has been found to be 58.4 kJ mol⁻¹ using variable temperature ¹H NMR spectral studies. The semiempirical MO calculations, using AM1 method, also suggested the preference of boat conformation for the N-acyl derivatives 3-6.
Page(s): 1526-1536
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(09) [September 2007]

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