Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6958
Title: Strain diversity within <i style="">Mycobacterium avium </i>subspecies <i style="">paratuberculosis </i> — A review
Authors: Sohal, J S
Singh, S V
Singh, A V
Singh, P K
Keywords: Comparative genomics
Host adaptation
Host response
Inter-species transmission
<i>Mycobacterium avium </i>subspecies <i>paratuberculosis</i>
Paratuberculosis
Issue Date: Jan-2010
Publisher: CSIR
Abstract: <i>Mycobacterium avium </i>subspecies <i>paratuberculosis</i> (MAP), is the etiological agent of Johne’s disease (or paratuberculosis) in animals and has also been linked with Crohn’s disease of human beings. Extreme fastidious nature of the organism (MAP) has hampered studies on diversity within the organism. Studies based on phenotypic properties like growth rate, pigmentation, lipid profile etc., are unable to provide complete information on diversity of MAP organism in nature. However, with the advent of molecular assays (IS<i style="">900</i> RFLP, PFGE, IS<i style="">1311</i> PCR-REA, SSR typing, VNTR typing etc.) in last 2 decades, progress has been made to differentiate MAP strains. MAP isolates have been classified into various types and subtypes using these molecular tools. Optimization of these typing assays has led to generation of new information about MAP strains, subtypes, their comparative genomics, relative evolution, comparative virulence etc. Knowledge of strain diversity is important for better understanding of molecular and sero-epidemiology, infection and patho-biology, vaccine development and planning control strategies. The present review provides available information on MAP strains, host adaptations, their virulence, comparative genomics, relative genetic evolution and differentiation.
Description: 7-16
URI: http://hdl.handle.net/123456789/6958
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(01) [January 2010]

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