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Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.05 [2006] >
IJTK Vol.05(3) [July 2006] >
| Title: | Efficacy and safety of RA-11 (O) – A herbal analgesic cream |
| Authors: | Wadnap, Neelesh
Johnson, Jasmin
Bhatt, Narendra
Chitre, Deepa |
| Keywords: | Ayurvedic cream
Analgesic cream
Antiinflammatory cream
Herbal cream
Joints pain
Swelling |
| Issue Date: | Jul-2006 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.8: A61K36/00,A61P7/10, A61P19/00, A61P19/02, A61P19/06, A61P21/00, A61P29/00, A61P19/02 |
| Abstract: | The plant based multi-component formulation; RA-11 (O) has
been conceived and developed from Ayurvedic science for topical application in
patients with joints pain and swelling. The clinical study was undertaken to
test the safety and efficacy of RA-11 (O). Thirty patients, who had joints pain
and swelling, with restriction of movement, and were able to understand and
sign the informed consent form, were included in the study. The patients were
advised to apply the study drug thrice daily for 14 days. There was significant
reduction in the Visual Analog Scale score for joints pain on 7th
and 14th day (p<0.001). The physician’s assessment of disease
showed improvement with 9 patients being a symptomatic on 7th day of
treatment and 25 patients being a symptomatic on 14th day of
treatment. The patient’s assessment of disease showed a similar resolution of
symptoms with 6 patients noting no symptoms on 7th day of treatment
(p<0.01) and 23 patients being a symptomatic on 14th day of
treatment (p<0.001). Body weight and vital parameters were unaffected over
the course of the study. Skin irritation test showed no irritation in any of
the patients and no dermal side effects were observed on follow up over 14
days. The domains of pain, freedom of movement and global assessment, which are
the core variables in any study of joints pain and swelling; showed significant
improvement in the study. RA-11 (O) has been reported as a safe and effective topical
cream for relief of joints pain and swelling. |
| Page(s): | 384-387 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.05(3) [July 2006]
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