NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.46B [2007] >
IJC-B Vol.46B(09) [September 2007] >


Title: Biocatalytic acylation studies on novel 3-aryl-3-hydroxymethyl-2, 3-dihydro-4H-1- benzopyran-4-ones
Authors: Kumar, Vijayendra
Rajesh Kumar
Raunak
Poonam
Sharma, Sunil K
Prasad, Ashok K
Cholli, Ashok L
Olsen, Carl E
Parmar, Virinder S
Keywords: Isoflavanones
Biocatalytic resolution
Lipase
CAL-B
Acylating agents
Heptanoic anhydride
Issue Date: Sep-2007
Publisher: CSIR
Abstract: (±)-3-Aryl-3-hydroxymethyl-2,3-dihydro-4H-1- benzopyran-4-ones have been synthesized in four steps starting with the coupling of resorcinol with corresponding phenylacetic acid leading to the formation of 2,4-dihydroxyphenyl aryl ketones, which upon monomethylation/benzylation and hydroxymethylation afford (±)-hydroxymethylisoflavanones in 65-70% yields. These isoflavanones have been subjected to lipase-catalyzed acylation reactions under different conditions (for optimization) of varying solvents, enzymes and acylating agents. Candida antarctica lipase B in tetrahydrofuran using heptanoic anhydride at 90 ºC is found to be the best reaction protocol for the biocatalytic reaction.
Page(s): 1501-1510
ISSN: 0376-4699
Source:IJC-B Vol.46B(09) [September 2007]

Files in This Item:

File Description SizeFormat
IJCB 46B(9) (2007) 1501-1510.pdf156.56 kBAdobe PDFView/Open
 Current Page Visits: 570 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 592677 since 06-Feb-2009  Last updated on 18-Sep-2014Webmaster: nopr@niscair.res.in