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Title: Diuretic activity of coconut husk Mashi—an Ayurvedic formulation
Authors: Rathi, BS
Baheti, AM
Khandelwal, KR
Parakh, SR
Bodhankar, SL
Keywords: Anterdhum Padhati
Ayurvedic drug
Bahirdhum Padhati
Coconut husk
Diuretic activity
Issue Date: Oct-2006
Publisher: CSIR
IPC CodeInt. Cl.8: A61K36/00, A61P13/00, A61P13/02
Abstract: Coconut husk Mashi is an Ayurvedic formulation prepared by Anterdhum Padhati (APM) and Bahirdhum Padhati (BPM). Though, Ayurvedic practitioners use coconut husk Mashi for diuretic activity, no systematic studies are reported with regard to the verification of the traditional medicinal claims of Mashi. The present study was undertaken to investigate and rationalize the diuretic activity of APM and BPM in experimental rats. The diuretic properties of APM and BPM were evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male albino rats. Different concentrations of Mashi (250 mg/kg, 500 mg/kg) were orally administered to hydrated rats and their urine output was immediately measured after 5hrs of treatment. Frusemide (10 mg/kg) was used as reference drug while normal saline (0.9%) solution was used as control. BPM exhibited dose dependent diuretic property and APM failed to show activity. The onset of diuretic action was extremely prompt (within 1hr) and lasted throughout the study period (up to 5 hrs). BPM at 500 mg/kg displayed highest activity with potency value of 0.92 and same dose of APM gave a value of 0.24. BPM caused mark increased in Na+, K+ and Cl- level. The results suggest that BPM possess significant diuretic activity.
Page(s): 471-473
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Source:IJTK Vol.05(4) [October 2006]

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