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Research Journals >
Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.05 [2006] >
IJTK Vol.05(4) [October 2006] >
| Title: | Diuretic activity of coconut husk Mashi—an Ayurvedic formulation |
| Authors: | Rathi, BS
Baheti, AM
Khandelwal, KR
Parakh, SR
Bodhankar, SL |
| Keywords: | Anterdhum Padhati
Ayurvedic drug
Bahirdhum Padhati
Coconut husk
Diuretic activity
Mashi |
| Issue Date: | Oct-2006 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.8: A61K36/00, A61P13/00, A61P13/02 |
| Abstract: | Coconut husk Mashi
is an Ayurvedic formulation prepared by Anterdhum
Padhati (APM) and Bahirdhum Padhati
(BPM). Though, Ayurvedic practitioners use coconut husk Mashi for diuretic activity, no systematic studies are reported
with regard to the verification of the traditional medicinal claims of Mashi. The present study was undertaken
to investigate and rationalize the diuretic activity of APM and BPM in
experimental rats. The diuretic properties of APM and BPM were evaluated by
determination of urine volume, electrolyte concentration and diuretic potency
in male albino rats. Different concentrations of Mashi (250 mg/kg, 500 mg/kg) were orally administered to hydrated
rats and their urine output was immediately measured after 5hrs of treatment.
Frusemide (10 mg/kg) was used as reference drug while normal saline (0.9%)
solution was used as control. BPM exhibited dose dependent diuretic property
and APM failed to show activity. The onset of diuretic action was extremely
prompt (within 1hr) and lasted throughout the study period (up to 5 hrs). BPM
at 500 mg/kg displayed highest activity with potency value of 0.92 and same
dose of APM gave a value of 0.24. BPM caused mark increased in Na+,
K+ and Cl- level. The results suggest that BPM possess
significant diuretic activity. |
| Page(s): | 471-473 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.05(4) [October 2006]
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