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Title: Synthesis and lipase-catalysed enantioselective acylation studies on ethyl 4-aryl-3,4-dihydropyrimidin-2(1H)-ones
Authors: Prasad, Ashok K
Arya, Pragya
Bhatia, Sumati
Sharma, Raman K
Singh, Rishipal
Singh, Brajendra K
Eycken, Erik Van der
Singh, Rajpal
Olsen, Carl E
Parmar, Virinder S
Keywords: Dihydropyrimidinones;Biginelli condensation;CAL-L(A);enantioselective acylation
Issue Date: Dec-2009
Publisher: CSIR
Abstract: A series of different analogs of 4-aryl-3,4-dihydropyrimidin-2(1H)-one have been synthesized and their biocatalytic resolution has been carried out using immobilized lipase CAL-L(A) (immobilized on accurel). The systematic one-step procedure is developed for the synthesis of optically enriched ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 8a-d and acylated ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates 9a-e, 10a-e, 11b-d and 12a-e, by the enantioselective acylation of racemic ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates using CAL-L(A).
Page(s): 1738-1748
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.48B(12) December 2009]

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