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IJC-B Vol.48B(12) December 2009] >


Title: Synthesis and studies on antimicrobial, antiinflammatory and antiproliferative activities of heterocycles derived from 4-/5-/6-/7-nitro/5-fluoro/chloro/bromoindole-2-carbohydrazides
Authors: Narayana, B
Ashalatha, B V
Raj, K K Vijaya
Sarojini, B K
Keywords: Synthesis
heterocycles
indoles
antimicrobial
anti-inflammatory
antiproliferative activity
Issue Date: Dec-2009
Publisher: CSIR
Abstract: Synthesis and studies on antimicrobial, antiinflammatory and antiproliferative activities of heterocycles derived from 4-/5-/6-/7-nitro/5-fluoro/chloro/bromoindole-2-carbohydrazides are discussed. 4-/5-/6-/7-nitroindole-2-carbohydrazides and 5-fluoro/chloro/bromoindole-2-carbohydrazides on treatment with acetyl acetone in methanol have resulted in 2-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-4-/5-/6-/7-nitro-1H-indoles and 2-[(3,5-dimethyl-1H-pyrazol-1-yl) carbonyl]-5-fluoro/chloro/bromo-1H-indoles respectively. 4-/6-/7-nitroindole-2-carbohydrazides on treatment with CS2/KOH in methanol have yielded 5-(4-/6-/7-nitro-1H-indol-2-yl)-1,3,4-oxadiazole-2-thiol and with cyanogen bromide yielded 5-(4-/6-/7-nitro-1H-indol-2-yl)-1,3,4-oxadiazol-2-amine. Nitroindole-2-carbohydrazides are also treated with various aromatic carboxylic acids and triethyl orthoformate yielded 2-[5-(aryl)-1,3,4-oxadiazol-2-yl]-4-/5-/6-/7-nitro-1H-indoles and 4-/6-/7-nitro-2-(1,3,4-oxadiazol-2-yl)-1H-indoles, respectively. Structures of the newly synthesized compounds are characterized by analytical and spectral data.
Page(s): 1794-1805
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(12) December 2009]

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