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IJC-B Vol.48B(12) December 2009] >


Title: Synthesis and antimicrobial activity of 5-(2-aminothiazol-4-yl)-3, 4-dihydro-4-phenyl pyrimidin-2(1H)-one
Authors: Lanjewar, Kushal R
Rahatgaonkar, Anjali M
Chorghade, Mukund S
Saraf, Binda D
Keywords: Pyrimidines
bromopyrimidines
thiazoles
cyclocondensation reaction
antimicrobial activity
Issue Date: Dec-2009
Publisher: CSIR
Abstract: A series of hybrid 5-(2-aminothiazol-4-yl)-3,4-dihydro-4-phenyl pyrimidin-2(1H)-ones (ATDPP) are reported. Efficient cyclocondensation of appropriately substituted 5-(2-bromoacetyl)-3,4-dihydro-4-phenylpyrimidine-2(1H)-ones (BADPP) with thiourea in ethanol proceeds in high yield to furnish the corresponding ATDPPs. Dihydropyrimidine carboxylates (DHPMS) and their bromo derivatives are the key substrates for cyclocondensation. The ATDPPS revealed biological activity as antimicrobial and antifungal agents against S. aureus, P. aurogenosa, K. pneumonae and C. albicans.
Page(s): 1732-1737
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(12) December 2009]

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