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Title: Lipase-catalyzed regio- and stereoselective deacylation: Separation of anomers of peracylated , -D-ribofuranosides
Authors: Sharma, Raman K
Aggarwal, Neha
Arya, Anu
Olsen, Carl E
Parmar, Virinder S
Prasad, Ashok K
Keywords: Anomeric mixture;Lipozyme® TL IM;peracylated ,-D-ribofuranosides;regio- and stereo- ­selective deacylation
Issue Date: Dec-2009
Publisher: CSIR
Abstract: Efficient regio- and stereoselective deacylation of acyloxy function involving C-5′ hydroxyl group of -anomer over the other similar C-5′ acyl group of -anomer and acyl groups involving secondary hydroxyls in anomeric mixture of peracylates of D-ribose has been achieved during deacylation reaction mediated by Lipozyme® TL IM (Thermomyces lanuginosus lipase immobilized on silica). This enzymatic methodology has been efficiently used for the separation of anomeric mixtures of peracylated ,-D-ribofuranosides.
Page(s): 1727-1731
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.48B(12) December 2009]

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