NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(12) December 2009] >

Title: Novel oligonucleotide analogues based on morpholino nucleoside subunits – Antisense technologies: New chemical possibilities
Authors: Abramova, Tatyana V
Kassakin, Marat F
Silnikov, Vladimir N
Keywords: Antisense technologies
oligonucleotide analogues,
Issue Date: Dec-2009
Publisher: CSIR
Abstract:  Even several decades after pioneer publications there is continued interest in the construction and synthesis of a variety of novel oligonucleotide analogues. The first oligonucleotide analogues which had a regular, predetermined structure containing nucleoside units joined with carbonate, carbamate, hydroxyacetate and hydroxyacetamide tethers have been developed in the 1970s. Further progress in oligonucleotide synthetic methods during the 1980s stimulated the development of a variety of oligonucleotide analogues containing modified carbohydrate and phosphate backbones. Particular attention has been given to the PNA (peptide nucleic acids), morpholino, and negatively charged PNA oligonucleotide analogues, which showed the most promise in a number of biological applications, such as diagnostics, nucleic acid analyses, and gene expression. The cost of parent compounds and oligonucleotide analogue synthesis is one of the most limiting factors to broad application. Studies that succeed in resolving this cost problem in the most effective way would be beneficial. Herein is presented a short review on oligonucleotide analogues that can be synthesized from inexpensive parent compounds — ribonucleosides — with or without the protection of heterocyclic bases, and with minimal protection of other reactive functions.
Page(s): 1721-1726
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(12) December 2009]

Files in This Item:

File Description SizeFormat
IJCB 48B(12) 1721-1726.pdf143.89 kBAdobe PDFView/Open
 Current Page Visits: 98 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167633 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: