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Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.05 [2006] >
IJTK Vol.05(2) [April 2006] >
| Title: | Antihypertensive activity of Amuri from Musa paradisiaca L. |
| Authors: | B, Jaiprakash
P V, Habbu P V
R V, Karadi
M S, Lavalhe
R V, Savadi
R, Sudha
S D, Joshi |
| Keywords: | Amuri
Kayakarpam
Musa paradisiaca
Antihypertensive activity |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl8: A61K36/00, A61P9/12 |
| Abstract: | Amuri is a Kayakarpam preparation
in Siddha System of Medicine for treatment of many diseases. In the present
investigation, an attempt has been made to study the antihypertensive activity
of Amuri from plantain (Banana tree (Musa paradisiaca L.) through animal
models. The drug was screened for all possible mechanisms that alter blood
pressure like diuretic activity in albino rats, antianxiety activity in mice,
calcium channel blocking activity and b-adrenoreceptor
blocking activity on isolated frog heart. Amuri
from Banana tree exhibited significant diuretic activity (p<0.001) at a dose
level of 8ml and 10ml/kg bw, and was comparable to hydrochlorthiazide.
Treatment with Amuri did not have any
antianxiety activity. Amuri also
produced significant positive ionotropic and negative chronotropic effect
similar to that of digoxin on isolated frog heart. This action was not
antagonized by propranalol. Pretreatment with verapamil significantly reduced
the cardiotonic activity. Amuri produced
a significant increase in the force of contraction and heart rate (p<0.001).
The action of Amuri on isolated frog
heart was not dose dependent. |
| Page(s): | 197-200 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.05(2) [April 2006]
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