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Title: Antihypertensive activity of Amuri from Musa paradisiaca L.
Authors: B, Jaiprakash
P V, Habbu P V
R V, Karadi
M S, Lavalhe
R V, Savadi
R, Sudha
S D, Joshi
Keywords: Amuri;Kayakarpam;Musa paradisiaca;Antihypertensive activity
Issue Date: Apr-2006
Publisher: CSIR
IPC Code: Int. Cl8: A61K36/00, A61P9/12
Abstract: Amuri is a Kayakarpam preparation in Siddha System of Medicine for treatment of many diseases. In the present investigation, an attempt has been made to study the antihypertensive activity of Amuri from plantain (Banana tree (Musa paradisiaca L.) through animal models. The drug was screened for all possible mechanisms that alter blood pressure like diuretic activity in albino rats, antianxiety activity in mice, calcium channel blocking activity and b-adrenoreceptor blocking activity on isolated frog heart. Amuri from Banana tree exhibited significant diuretic activity (p<0.001) at a dose level of 8ml and 10ml/kg bw, and was comparable to hydrochlorthiazide. Treatment with Amuri did not have any antianxiety activity. Amuri also produced significant positive ionotropic and negative chronotropic effect similar to that of digoxin on isolated frog heart. This action was not antagonized by propranalol. Pretreatment with verapamil significantly reduced the cardiotonic activity. Amuri produced a significant increase in the force of contraction and heart rate (p<0.001). The action of Amuri on isolated frog heart was not dose dependent.
Page(s): 197-200
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.05(2) [April 2006]

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