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IJC-B Vol.45B(12) December 2006] >


Title: Synthesis, antibacterial and antifungal activity of some new pyrido quinazolones
Authors: Singh, V K
Pandey, V K
Keywords: Tetrahydroquinazolines
calcium antagonists
alkyli-deno/aryldeno-bis-ureas
antibacterial
antifungal
Issue Date: Dec-2006
Publisher: CSIR
IPC CodeInt.Cl.8 C07D
Abstract: Alkylideno/arylideno bis ureas 1 synthesized by ureido­alkylation in the presence of alcohols–which on treatment with p-amino­benzoic acid results in 4-aryl-6-carboxylato-1,2,3,4-tetra­hydroquinazolines 2. Reaction of 2 with benzoin in presence of polyphosphoric acid yields 4-aryl-8,9-diphenyl-1,4 dihydro-3H, 7-oxo-1,3-diaza anthracene-2,6-dione 3. Condensation of 3 with aromatic primary amine affords N-aryl-8,9-diphenyl (-2-oxo-pyrido [g]-4-aryl-2-oxo-1,3-dihydro quinazolines 4. The new compound 4 has been screened for their antibacterial and antifungal activities.
Page(s): 2745-2748
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(12) December 2006]

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