NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(12) December 2006] >


Title: Diastereoselective synthesis of 1,3-disubstituted 1,2,3,4 tetrahydro--carbolines using Pictet-Spengler reaction in non-acidic aprotic media
Authors: Sharma, S D
Bhaduri, Susmita
Kaur, Gurpreet
Keywords: Pictet-Spengler reaction
-carbolines
diastereoselection
asymmetric synthesis
enantiopure
Issue Date: Dec-2006
Publisher: CSIR
IPC CodeInt.Cl.8 C07D
Abstract: L-Tryptophan methyl ester hydrochloride 2 undergoes Pictet-Spengler reaction with aromatic aldehydes in non-acidic aprotic media to furnish tetrahydro--carbolines. The reaction proceeds in good yield and excellent diastereoselectivity giving cis isomers 4a-c and 6a as the major product. Use of an optically active aldehyde 10 for this reaction yields enantiopure cis-1,3-disubstituted 1,2,3,4-tetrahydro--carboline 11.
Page(s): 2710-2715
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(12) December 2006]

Files in This Item:

File Description SizeFormat
IJCB 45B(12) 2710-2715.pdf56.37 kBAdobe PDFView/Open
 Current Page Visits: 425 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 557839 since 06-Feb-2009  Last updated on 15-Jul-2014Webmaster: nopr@niscair.res.in