22-May-2013
12:15:31 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(12) December 2006] >
| Title: | Synthesis of 3-amino-2-methyl/ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d] pyrimidin-4(3H)-one and its Schiff bases as possible antimicrobial and non-steroidal antiinflammatory agents |
| Authors: | Narayana, B
Ashalatha, B V
Raj, K K Vijaya
Kumari, N Suchetha |
| Keywords: | Synthesis
thienopyrimidine
Schiff bases
antibacterial
non-steroidal antiinflammatory |
| Issue Date: | Dec-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 1 has been converted into ethyl 2-(acetylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2a and ethyl 2-(propionylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2b. Compounds 2a and 2b on treatment with hydrazine hydrate give 3-amino-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4(3H)-one 3a and 3-amino-2-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4(3H)-one 3b respectively. Compounds 3a and 3b have been treated with aromatic aldehydes to get Schiff bases 4a-l and 5a-l. The compounds have been characterized by spectral analysis and screened for antibacterial and antifungal activity. Eight compounds have also been screened for their antiinflammatory activity. A few of the compounds exhibit promising biological activity. |
| Page(s): | 2696-2703 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(12) December 2006]
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