NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(12) December 2006] >

Title: Synthesis of 3-amino-2-methyl/ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d] pyrimidin-4(3H)-one and its Schiff bases as possible antimicrobial and non-steroidal antiinflammatory agents
Authors: Narayana, B
Ashalatha, B V
Raj, K K Vijaya
Kumari, N Suchetha
Keywords: Synthesis
Schiff bases
non-steroidal antiinflammatory
Issue Date: Dec-2006
Publisher: CSIR
IPC CodeInt.Cl.8 C07D
Abstract: Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 1 has been converted into ethyl 2-(acetylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2a and ethyl 2-(propionylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2b. Compounds 2a and 2b on treatment with hydrazine hydrate give 3-amino-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4(3H)-one 3a and 3-amino-2-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4(3H)-one 3b respectively. Compounds 3a and 3b have been treated with aromatic aldehydes to get Schiff bases 4a-l and 5a-l. The compounds have been characterized by spectral analysis and screened for antibacterial and antifungal activity. Eight compounds have also been screened for their antiinflammatory activity. A few of the compounds exhibit promising biological activity.
Page(s): 2696-2703
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(12) December 2006]

Files in This Item:

File Description SizeFormat
IJCB 45B(12) 2696-2703.pdf124.96 kBAdobe PDFView/Open
 Current Page Visits: 82 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 135922 since 01-Sep-2015  Last updated on 27-May-2016Webmaster: