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Title: Synthesis of 3-amino-2-methyl/ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d] pyrimidin-4(3H)-one and its Schiff bases as possible antimicrobial and non-steroidal antiinflammatory agents
Authors: Narayana, B
Ashalatha, B V
Raj, K K Vijaya
Kumari, N Suchetha
Keywords: Synthesis
Schiff bases
non-steroidal antiinflammatory
Issue Date: Dec-2006
Publisher: CSIR
Series/Report no.: Int.Cl.8 C07D
Abstract: Ethyl 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 1 has been converted into ethyl 2-(acetylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2a and ethyl 2-(propionylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate 2b. Compounds 2a and 2b on treatment with hydrazine hydrate give 3-amino-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4(3H)-one 3a and 3-amino-2-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimid-4(3H)-one 3b respectively. Compounds 3a and 3b have been treated with aromatic aldehydes to get Schiff bases 4a-l and 5a-l. The compounds have been characterized by spectral analysis and screened for antibacterial and antifungal activity. Eight compounds have also been screened for their antiinflammatory activity. A few of the compounds exhibit promising biological activity.
Description: 2696-2703
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(12) December 2006]

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