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IJC-B Vol.45B(11) [November 2006] >


Title: Correlation between the pKa and pharmacological properties of some imidazolin-5(4H)-ones, their precursors and Schiff’s bases
Authors: Gupta, J K
De, Biplab
Saravanan, V S
Keywords: Imidazolin-5(4H)-ones
Schiff bases
potentiometric method
analgesic activity
CNS depressant property
Issue Date: Nov-2006
Publisher: CSIR
IPC CodeInt. Cl.8 C07D
Abstract: The pKa value of some synthesized imidazolin-5(4H)-ones and their precursors, Schiff’s bases are determined by potentiometric method and the analgesic activity and CNS depressant property are evaluated, which are correlated with the pKa values. It is found that a correlation established in best fit curve of 3rd order polynomial equation.
Page(s): 2580-2582
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(11) [November 2006]

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