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Title: Bioactive diterpenes from the mangrove Avicennia officinalis Linn
Authors: Subrahmanyam, C
Kumar, S Ratna
Reddy, G Damodar
Keywords: Avicennia officinalis;diterpenes;antimicrobial activity;Mangrove
Issue Date: Nov-2006
Publisher: CSIR
IPC Code: Int.Cl.8 A61K
Abstract:  The hexane extract of the roots of A. officinalis Linn, collected from the coast of Ongole, A.P., has yielded ent-16-hydroxy-3-oxo-13-epi-manoyl oxide, rhizophorin-B 1 and compound A, while ethyl acetate extract give triacontan-1-ol, ribenone, excoecarin A, ent-16-hydroxy-3-oxo-13-epi-manoyl oxide, ent-15-hydroxy-labda-8(17),13E-dien-3-one, compound A, 1 and ent-3a,15-dihydroxy-labda-8(17),13E-diene. Compound A is identified as ent-(13S)-2,3-seco-14-labden-2,8-olide-3-oic acid 2, a new diterpenoid, on the basis of its spectral data. Excoecarin A, ent-16-hydroxy-3-oxo-13-epi-manoyl oxide and ent-15-hydroxy-labda-8(17),13E-dien-3-one show moderate antifungal activities against Rhizopus oryzae and Aspergillus niger while rhizophorin-B 1 exhibits antibacterial activity against Bacillus subtilis.
Page(s): 2556-2557
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(11) [November 2006]

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