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Title: A simple synthesis of -methyl--keto acids
Authors: Pawar, B V
Waghmare, B Y
Lokhande, P D
Keywords: Morpholinoacetonitrile;-keto acids;conjugate addition;enolate alkylation;lactone
Issue Date: Nov-2006
Publisher: CSIR
IPC Code: Int. Cl.8 C07C
Abstract: The reaction of the anion derived from -marpholinonitriles with methyl acrylate in excess of NaH in DMF gives -keto acids in high yield. This process is highly convenient for the synthesis of various -substituted--keto acids, which can be easily converted to naturally occurring -substituted--lactones.
Page(s): 2549-2551
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(11) [November 2006]

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