Please use this identifier to cite or link to this item:
Title: Synthesis and biological evaluation of ureido derivatives as VLA-4 antagonists
Authors: Sattigeri, Viswajanani J
Soni, Ajay
Gupta, Lavleen K
Ray, Abhijit
Ahmad, Sharif
Gupta, Jang B
Salman, Mohammad
Keywords: VLA-4 antagonists;bioisosteres;ureido derivatives
Issue Date: Nov-2006
Publisher: CSIR
IPC Code: Int. Cl.8 C07D
Abstract: Bioisosteric replacement based design strategy was employed in order to improve pharmacokinetic properties of TBC-3486, a potent VLA-4 antagonist. However, the newly synthesized analogs did not show any significant activity.
Page(s): 2534-2541
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(11) [November 2006]

Files in This Item:
File Description SizeFormat 
IJCB 45B(11) 2534-2541.pdf82.23 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.