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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(11) [November 2006] >
| Title: | Synthesis and biological evaluation of ureido derivatives as VLA-4 antagonists |
| Authors: | Sattigeri, Viswajanani J
Soni, Ajay
Gupta, Lavleen K
Ray, Abhijit
Ahmad, Sharif
Gupta, Jang B
Salman, Mohammad |
| Keywords: | VLA-4 antagonists
bioisosteres
ureido derivatives |
| Issue Date: | Nov-2006 |
| Publisher: | CSIR |
| IPC Code: | Int. Cl.8 C07D |
| Abstract: | Bioisosteric replacement based design strategy was employed in order to improve pharmacokinetic properties of TBC-3486, a potent VLA-4 antagonist. However, the newly synthesized analogs did not show any significant activity. |
| Page(s): | 2534-2541 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(11) [November 2006]
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