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Title: Synthesis, insecticidal and antimicrobial activities of some heterocyclic derivatives of quinazolinone
Authors: Singh, Tripti
Sharma, Shalabh
Srivastava, Virendra Kishore
Kumar, Ashok
Keywords: Triazinoquanizolinone;Periplaneta americana;insecticidal acitivity;antifungal;antibacterial activity
Issue Date: Nov-2006
Publisher: CSIR
IPC Code: Int. Cl.8 C07D
Abstract: Some new 4-phenyl-2,3-dihydro-6-(substitutedaminoethyl)-10-iodo[1,2,4]-triazino[2,3-c]-quina-zolin-5-ones 6-14 have been synthesized from 4-(phenyl-2,3-dihydro-6-methyl-10-iodo [1,2,4]-triazino[2,3-c]quinazolin-5-one 5 by introducing different heterocyclic nuclei. Compounds 5 and 6-14 have been screened for insecticidal, anti-fungal and antibacterial activities. Compound 4-phenyl-2, 3-dihydro-6-(b-naphthylaminoethyl)-10-iodo[1, 2, 4]-triazino[2,3-c]-quinazolin-5-one 14 has been found to be the most potent compound of the present study which shows mortality of insects at 190.6 min while standard compounds exhibit at 280 min at a concentration of 5 g/L. Moreover, this compound also possesses anti-bacterial activity. The structures of these compounds have been elucidated by IR, 1H NMR, mass spectroscopy and elemental analysis.
Page(s): 2558-2565
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(11) [November 2006]

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