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Title: Synthesis, insecticidal and antimicrobial activities of some heterocyclic derivatives of quinazolinone
Authors: Singh, Tripti
Sharma, Shalabh
Srivastava, Virendra Kishore
Kumar, Ashok
Keywords: Triazinoquanizolinone
<i style="">Periplaneta americana</i>
insecticidal acitivity
antibacterial activity
Issue Date: Nov-2006
Publisher: CSIR
Series/Report no.: Int. Cl.<sup>8</sup> C07D
Abstract: Some new 4-phenyl-2,3-dihydro-6-(substitutedaminoethyl)-10-iodo[1,2,4]-triazino[2,3-<i style="">c</i>]-quina-zolin-5-ones <b style="">6-14</b> have been synthesized from 4-(phenyl-2,3-dihydro-6-methyl-10-iodo [1,2,4]-triazino[2,3-<i style="">c</i>]quinazolin-5-one <b style="">5</b> by introducing different heterocyclic nuclei. Compounds <b style="">5</b> and <b style="">6-14</b> have been screened for insecticidal, anti-fungal and antibacterial activities. Compound<b style=""> </b>4-phenyl-2, 3-dihydro-6-(b-naphthylaminoethyl)-10-iodo[1, 2, 4]-triazino[2,3-<i style="">c</i>]-quinazolin-5-one <b style="">14 </b>has been found to be the most potent compound of the present study which shows mortality of insects at 190.6 min while standard compounds exhibit at 280 min at a concentration of 5 g/L. Moreover, this compound also possesses anti-bacterial activity. The structures of these compounds have been elucidated by IR, <sup>1</sup>H NMR, mass spectroscopy and elemental analysis.
Description: 2558-2565
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(11) [November 2006]

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