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Title: Synthesis, characterization and DNA binding and cleavage properties of copper(II)-tryptophan-tryptophan complex
Authors: Reddy, Pulimamidi R
Raju, Nomula
Reddy, Karnati V
Keywords: Coordination chemistry;Copper;Amino acids;Metallopeptides;Thermal denaturation;DNA quenching;DNA cleavage
Issue Date: Dec-2009
Publisher: CSIR
IPC Code: Int. Cl.9 C07C229/76; C07F1/08
Abstract: Reaction of copper(II) with tryptophan-tryptophan yields a 1:2 chloro bis(trp-trp) cuprate(II) complex. The complex exhibits absorption band at 620 nm (ε = 130 M -1 cm-1), which suggests a square pyramidal geometry at Cu(II) as observed for other Cu(II)-peptide complexes. The giso value of 2.09 for the complex agrees with a Cu(II) environment of distorted square pyramidal geometry. The mononuclear complex binds to calf thymus DNA through moderate intercalative and weak covalent interactions. It converts the supercoiled plasmid pUC19 DNA to the nicked circular form under physiological conditions.
Page(s): 1638-1643
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.48A(12) [December 2009]

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