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Title: Synthesis, spectral studies and antimicrobial activity of 7-chloro-2-alkyl/ aryl-4-alkyl/aryl-3- arylidene-3H-1,5- benzodiazepines
Authors: Pathak, Vijai N
Joshi, Rahul
Gupta, Neetu
Keywords: Antimicrobial
Issue Date: Jul-2007
Publisher: CSIR
Abstract: Condensation of various β-diketones 2 with appropriate araldehydes 1 in the presence of piperidene has afforded 2-arylidene-1,3- diketones 3 which in turn on condensation with 4-chloro-1,2-phenylene diamine in acidic medium give a series of 7-chloro-2-alkyl / aryl-4-alkyl / aryl-3-arylidene-3H-1,5-benzodiazepines 5a-j. All the newly synthesized compounds are characterized on the basis of their spectral (IR, 1H NMR, Mass) and analytical data. Representative compounds have been screened for their antibacterial and antifungal activities. Some of the compounds have been found to exhibit promising antibacterial and antifungal activities.
Page(s): 1191-1197
ISSN: 0376-4699
Source:IJC-B Vol.46B(07) [July 2007]

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