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IJEB Vol.47(12) [December 2009] >


Title: Wound healing activity of methanolic extract of leaves of Alternanthera brasiliana Kuntz using in vivo and in vitro model
Authors: Barua, C C
Talukdar, A
Begum, S A
Sarma, D K
Pathak, D C
Barua, A G
Bora, R S
Keywords:  Alternanthera brasiliana
Chorioallantoic membrane model
Excision wound
Incision wound
Wound healing
Issue Date: Dec-2009
Publisher: CSIR
Abstract:  Wound healing activity of methanolic extract of leaves of Alternanthera brasiliana Kuntz was studied by excision and incision wound model (in vivo) in Sprague Dawley rats and by Chorioallantoic membrane (CAM) model (In vitro) in 9 day old embryonated chicken eggs. In excision wound model, compared to the control group, per cent contraction of wound was significantly higher in A. brasiliana (5% w/w ointment) treated group. In incision wound model, tensile strength of the healing tissue after treatment with A. brasiliana was found to be significantly higher compared to the control group indicating better wound healing activity of the test plant. These findings were also confirmed by histopathological examination. The extract also promoted angiogenesis as evidenced by CAM model. The results suggested that methanolic extract of A. brasiliana possess significant wound healing potential in normal wound.
Page(s): 1001-1005
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.47(12) [December 2009]

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